SYNTHESIS, CHARACTERISATION AND ANTIMICROBIAL STUDIES OF SOME NOVEL ISOXAZOLINE DERIVATIVES FROM FLUORINATED CHALCONES

Sandip U Agare1, Mahesh P. More2 and Tanuja V Kadre3*

Abstract: In the present investigation, a set of novel fluorine containing isoxazoline derivatives 3(a-i) were synthesized by refluxing fluorinated chalcones 2(a-i) with hydroxylamine hydrochloride under basic condition. The synthesized isoxazoline derivatives were confirmed by using spectroscopic techniques such as FT-IR, NMR, CHN and HRMS. Synthesized derivatives 3(a-i) evaluated for in-vitro antimicrobial studies. Antimicrobial study reveals that compounds 3(c-d) for S. aureus, 3(b, c and f) for B. subtilis, 3(a-e, and i) for E. coli, 3(b-d, and g) for P. aeruginosa exhibited excellent antimicrobial activity respectively as compared with standard streptomycin.  
Keywords: Chalcone, Isoxazoline, Fluorinated, Antibacterial, gram-positive and negative microorganisms.